Gene Expression
View Structural - Cellular
 The department has five research groups studying mechanisms of transcriptional regulation in eucaryotes. The spectrum of research ranges from studies on the fundamental mechanisms of transcription in yeast to characterization of aberrant gene regulation in human cancers. The research utilizes emerging technologies in molecular genetics, cellular biochemistry, and biophysical chemistry to address critical questions in one of the most complex processes in a living organism. InterestsEffect of Acidosis on Renal Gene Expression: Dr. CurthoysReconstitution of Yeast Chromatin; Chromatin Structure and the Regulation of Gene Expression: Dr. Laybourn Transcriptional Activation by the Human T-Cell Leukemia Virus Tax Protein; Involvement of Coactivators and Tumor Suppressors: Dr. Nyborg Fundamental Transcription and Regulation Mechanisms of RNA Polymerases I and III in Eukaryotic Cells: Dr. Paule Mechanisms of Transcriptional Initiation by RNA Polymerase II: Dr. Stargell Departmental CollaborationsStructural Analysis of RNA Polymerase II General Transcription Factors: Dr. StargellTBP Mutants that Specifically Affect Rribosomal RNA Transcription: Dr. Paule & Dr. Stargell Viral Transactivation in a Chromatin Context: Dr. Laybourn & Dr. Nyborg Structure Function of Transcription Factors: Dr. Laybourn High Resolution Structural Studies on Viral Activator Complexes: Dr. Luger & Dr. Nyborg Mechanism of RNA Polymerase I Nucleosome Stripping from Transcribed Ribosomal RNA Genes: Dr. Paule, Dr. Luger & Dr. Laybourn
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