ProfessorOffice: MRB 279Phone: 970-491-5100Education: Ph.D., University of California, DavisEmail: email@example.comResearch Title: Improving student learning outcomes through active learning approaches and engagment through research and socio-scientific issues.
Bell, G. E., Sanchez-Pescador, R., Laybourn, P. J., and Najarian, R. C. "Exon duplication and divergence in the human preproglucagon gene," Nature 304, 368-371 (1983).
Dahmus, M. E., Laybourn, P. J., and Boorebaeck, C. A. K. "Production of monoclonal antibody against electrophoretically purified RNA polymerase II subunits using in vitro immunization," Molec. Immunol. 25, 997-1003 (1988).
Laybourn, P. J., and Dahmus, M. E. "Transcription dependent structural changes in the C-terminal domain of mammalian RNA polymerase subunit IIa/o," J. Biol. Chem. 264, 6693-6698 (1989).
Payne, J. M., Laybourn, P. J., and Dahmus, M. E. "The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the C-terminal domain of subunit Iia," J. Biol. Chem. 264, 19621-19629 (1989).
Laybourn, P. J., and Dahmus, M. E. "Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription," J. Biol. Chem. 265, 13165-13173 (1990).
Laybourn, P. J., and Kadonaga, J. T. "Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II," Science 254, 238-245 (1991).
Laybourn, P. J., and Kadonaga, J. T. "Threshold phenomena and long-distance activation of transcription by RNA polymerase II," Science 257, 1682-1685 (1992).
Collins-Hicok, J., Lin, L., Spiro, C., Laybourn, P. J., Tschumper, R., Rapacz, B., and McMurray, C. T. "Induction of the rat prodynorphin gene through Gs-Coupled receptors may involve phosphorylation-dependent derepression and activation," Mol. Cell. Biol. 14, 2837-2848 (1994).
Pilon, J., Terrell, A., and Laybourn, P. J. Yeast chromatin reconstitution system using purified yeast core histones and yeast nucleosome assembly protein-1, Protein Expression and Purification 10, 132-140 (1997).
Campbell, K. M., Terrell, A. R., Laybourn, P. J., and Lumb, K. J. Intrisic Stuctural Disorder of the C-terminal Activation Domain from the bZIP Transcription Factor Fos, Biochemistry 39, 2708-2713 (2000).
Moss, D. R. and Laybourn, P. J. Upstream Nucleosomes and Rgr1p Are Required for Nucleosomal Repression of Transcription, Mol. Micro. 36, 1-14 (2000).
Martens, C., Krett, B., and Laybourn, P. J. RNA Polymerase II and TBP Occupy the Repressed CYC1 Promoter, Mol. Micro. 40, 1009-1019 (2001).
Georges, S. A., Kraus, W. L., Luger, K., Nyborg, J. K., and Laybourn, P. J. p300-Mediated Tax Transactivation from Recombinant Chromatin: Histone Tail Deletion Mimics Coactivator Function, Mol. Cell Biol. 22, 127-137 (2002).
Livengood J. A., Scoggin K.E., Van Orden K., McBryant S. J., Edayathumangalam R. S., Laybourn P. J., Nyborg J. K. "p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300," J. Biol. Chem. 277(11), 9054-9061 (2002).
Lemasson I., Polakowski N. J., Laybourn P. J., Nyborg J. K. "Transcription factor binding and histone modifications on the integrated proviral promoter in human T-cell leukemia virus-I-infected T-cells," J. Biol. Chem. 277(51), 49459-49465 (2002).
Marilley M., Radebaugh C. A., Geiss G. K., Laybourn P. J., Paule M. R. "DNA structural variation affects complex formation and promoter melting in ribosomal RNA transcription," Mol Genet Genomics. 267(6), 781-791 (2002).
Terrell, A. R., Wongwisansri, S., Pilon, J. L. and Laybourn, P. J. Reconstitution of Nucleosome Positioning, Remodeling, and Transcriptional Activation on the PHO5 Promoter, J. Biol. Chem. 277, 31038-31047 (2002).
Georges, S. A., Giebler, H. A., Cole, P. A., Luger, K., Laybourn, P. J., and Nyborg, J. K. "Tax Recruitment of CBP/p300, via the KIX Domain, Reveals a Potent Requirement for Acetyltransferase Activity That Is Chromatin Dependent and Histone Tail Independent." Mol. Cell Biol. 23, 3392-3404 (2003).
McBryant SJ, Abernathy SM, Laybourn PJ, Nyborg JK, Luger K.Preferential binding of the histone (H3-H4)2 tetramer by NAP1 is mediated by the amino terminal histone tails, J. Biol. Chem. 278, 44574-44583 (2003).
Wongwisansri, S., and Laybourn, P. J.Reconstitution of Yeast Chromatin Using yNAP1 Meth. Enzymol., vol. 375, pp. 103-117 (2004).
Lemasson, I., N. J. Polakowski, P. J. Laybourn, J. K. Nyborg. 2004, Transcription regulatory complexes bind the human T-cell leukemia virus 5' and 3' long terminal repeats to control gene expression, Mol Cell Biol. 24, 6117-6126.
Bao, Y., K. Konesky, Y. J. Park, S. Rosu, P.N. Dyer, D. Rangasamy, D. J. Tremethick, P.J. Laybourn, K. Luger. 2004, Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA, EMBO J. 23, 3314-3324.
Wongwisansri, S. and Laybourn, P. J. Disruption of the histone deacetylase gene RPD3 accelerates PHO5 activation kinetics through inappropriate Pho84p recycling, Euk. Cell 4, in press (2005).
I. Lemasson, N. J. Polakowski, P. J. Laybourn (corr. author), J. K. Nyborg, 2006, “Tax-dependent Displacement of Nucleosomes During Transcriptional Activation of Human T-cell Leukemia Virus, Type 1,” J. Biol. Chem. 281, 13075-13082.
K. L. Konesky, J. K. Nyborg, and P. J. Laybourn, 2006, “Tax Abolishes Histone H1 Repression of p300 Acetyltransferase Activity at the HTLV-1 Promoter,” J. Virol. 80, 10542-10553.
K. L. Konesky, and P. J. Laybourn, 2007, “Biochemical Analyses of Transcriptional Regulatory mechanisms in a Chromatin Context,” Methods, 41, 259-270.
J. M. Bogenberger and P. J. Laybourn, 2008, “Human T-lympotropic Virus Type 1 Protein Tax Reduces Histone Levels,” Retrovirology. 5:9.
Laybourn P., 2008, “The Ups and Downs of Tax and Histones in Adult T-cell Leukemogenesis,” Future Oncol. 4(3):311-7.
Balgopal, M. M., Laybourn, P. J., Wallace, A. M. and Brisch, E. "An Exploratory Study of How College Students Make Sense of Cancer in Writing-to-Learn Activities in Cell Biology." presented at NARST, Chicago, April 2015