Corey Rosenberg Assistant Professor

Office: ANATOMY & ZOOLOGY (AZ) E206F

Phone: (970) 491-4963

Google Scholar: https://scholar.google.com/citations?user=xxf7aHAAAAAJ&hl=en

About

Research- Regulation of gene expression changes associated with arbovirus susceptibility in mosquitoes

Arboviruses require an intermediate vector, eg, mosquitoes (arthropods), in order to be transmitted to vertebrates and humans. Aedes aegypti is a major vector of flavivirus pathogens, e.g., dengue, Zika, chikungunya viruses and is also competent for transmission of Rift Valley Fever virus. Culex tarsalis transmits West Nile virus and other arboviruses in the US. Mosquitoes show wide variability in differential gene expression patterns in response to arboviruses.

Cis-regulatory elements (CREs) are genomic regions adjacent to gene transcription start sites that mark transcriptional regulatory binding locations. Virtually nothing is known of CREs associated with arbovirus infection or whether chromatin modifications modulate mosquito host responses to infection. Culex and Aedes species transmit important exotic zoonotic arboviruses, e.g. Rift Valley fever virus, of potential concern to U.S. animal and public health. The objective of our current project is to identify CREs in mosquito genomes that contribute to vector competence. 

I use my maiden name, CL Campbell, in publications. 

 

Publications

  • Safety study of Rift Valley Fever human vaccine candidate (DDVax) in mosquitoes.Corey C. Rosenberg, Trey Snell, Susi L. Bennett, John Henry Wyckoff III, Darragh Heaslip, J Flatt, Emma Harris, Daniel Hartman, Elena Lian, Brian Bird, Mark Daniel Stenglein, Richard A. Bowen, Rebekah Kading Transboundary and Emerging Diseases.
  • Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters.Tony A. Schountz, Corey C. Rosenberg, Kaitlyn Marie Wagner, Joel Rovnak, C Martellaro, B L. DeBuysscher, H Feldmann, Joseph Brian Prescott Viruses, 3, 2019.
  • Involvement of pro-inflammatory macrophages in liver pathology of Pirital virus-infected of Syrian hamsters Hemorrhagic disease animal models in BSL3Aaron T. Phillips, Amber B. Rico, Corey C. Rosenberg, Amanda McGuire, Tawfik A. Aboellail, Sandra L. Quackenbush, Kenneth E. Olson, Tony Schountz, Viruses, 2018.
  • Alternative patterns of sex chromosome differentiation in Aedes aegypti (L)Corey C. Rosenberg, L. B. Dickson, Saul Lozano-Fuentes, P. Juneja, F. M. Jiggins, William C. Black IV BMC Genomics, 1, 2017.
  • Exon-Enriched Libraries Reveal Large Genic Differences Between Aedes aegypti from Senegal, West Africa, and Populations Outside AfricaL. B. Dickson, Corey C. Rosenberg, P. Juneja, F. M. Jiggins, M. Sylla, William C. Black IV G3 (Bethesda), 2, 2017.
  • Transcriptomic Signatures of Tacaribe Virus-Infected Jamaican Fruit BatsDiana L. Gerrard, Ann Hawkinson, Tyler Sherman, Cassandra M. Modahl, Gretchen Hume, Corey C. Rosenberg, Tony Schountz, Seth Frietze MSPHERE, 5, 2017.
  • Rapid evolution of mosquito anti-viral ncRNA pathway componentsNon-coding RNAs and Inter-kingdom CommunicationCorey C. Rosenberg, L. B. Dickson, William C. Black IV Springer International Publishing, 2016.
  • Experimental Evolution of an RNA Virus in Wild Birds: Evidence for Host-Dependent Impacts on Population Structure and Competitive FitnessNathan Dale Grubaugh, Darci Smith, Doug E. Brackney, Angela M. Bosco-Lauth, Joseph Robert Fauver, Corey C. Rosenberg, Todd A. Felix, Hannah Romo, Nisha K. Duggal, Elizabeth A. Dietrich, Tyler Hamilton Eike, Jennifer E. Beane, Richard A. Bowen, William C. Black IV, Aaron Cole Brault, Greg David Ebel PLOS PATHOGENS, 5, 2015.
  • Transcriptome Markers of Viral Persistence in Naturally-Infected Andes Virus (Bunyaviridae) Seropositive Long-Tailed Pygmy Rice RatsCorey C. Rosenberg, Fernando Torres-Perez, Mariana Acuna-Retamar, Tony Schountz PLOS ONE, 4, 2015.
  • A positively selected mutation in the WNV 2K peptide confers resistance to superinfection exclusion in vivoCorey C. Rosenberg, Darci Smith, Irma Sanchez-Vargas, Bo Zhang, Pei-Yong Shi, Greg David Ebel VIROLOGY, 2014.
  • MicroRNA levels are modulated in Aedes aegypti after exposure to Dengue-2Corey C. Rosenberg, T. Harrison, Ann Marie Hess, Greg David Ebel Insect Mol Biol, 1, 2014.
  • Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infectionM. Bonizzoni, W. A. Dunn, Corey C. Rosenberg, Kenneth E. Olson, O. Marinotti, A. A. James PLoS One, 11, 2012.
  • Strain Variation in the Transcriptome of the Dengue Fever Vector, Aedes aegyptiM. Bonizzoni, W. A. Dunn, Corey C. Rosenberg, Kenneth E. Olson, O. Marinotti, A. A. James G3 (Bethesda), 1, 2012.
  • A role for endosomal proteins in alphavirus dissemination in mosquitoesCorey C. Rosenberg, C. J. Lehmann, S. S. Gill, W. A. Dunn, A. A. James, Brian D. Foy Insect Mol Biol, 4, 2011.
  • RNA-seq analyses of blood-induced changes in gene expression in the mosquito vector species, Aedes aegyptiM. Bonizzoni, W. A. Dunn, Corey C. Rosenberg, Kenneth E. Olson, M. T. Dimon, O. Marinotti, A. A. James BMC Genomics, 2011.
  • Small RNA profiling of Dengue virus-mosquito interactions implicates the PIWI RNA pathway in anti-viral defenseAnn Marie Hess, A. N. Prasad, A. Ptitsyn, Greg David Ebel, Kenneth E. Olson, C. Barbacioru, C. Monighetti, Corey C. Rosenberg BMC Microbiol, 2011.
  • Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cellsJ. C. Scott, Doug E. Brackney, Corey C. Rosenberg, V. Bondu-Hawkins, B. Hjelle, Greg David Ebel, Kenneth E. Olson, Carol D. Brennan PLoS Negl Trop Dis, 10, 2010.
  • Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogensL. C. Bartholomay, R. M. Waterhouse, G. F. Mayhew, Corey C. Rosenberg, K. Michel, Z. Zou, J. L. Ramirez, S. Das, K. Alvarez, P. Arensburger, B. Bryant, S. B. Chapman, Y. Dong, S. M. Erickson, S. H. Karunaratne, V. Kokoza, C. D. Kodira, P. Pignatelli, S. W. Shin, D. L. Vanlandingham, P. W. Atkinson, B. Birren, G. K. Christophides, R. J. Clem, J. Hemingway, S. Higgs, K. Megy, H. Ranson, E. M. Zdobnov, A. S. Raikhel, B. M. Christensen, G. Dimopoulos, M. A. Muskavitch Science, 6000, 2010.
  • Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomicsP. Arensburger, K. Megy, R. M. Waterhouse, J. Abrudan, P. Amedeo, B. Antelo, L. Bartholomay, S. Bidwell, E. Caler, F. Camara, Corey C. Rosenberg, K. S. Campbell, C. Casola, M. T. Castro, I. Chandramouliswaran, S. B. Chapman, S. Christley, J. Costas, E. Eisenstadt, C. Feschotte, C. Fraser-Liggett, R. Guigo, B. Haas, M. Hammond, B. S. Hansson, J. Hemingway, S. R. Hill, C. Howarth, R. Ignell, R. C. Kennedy, C. D. Kodira, N. F. Lobo, C. Mao, G. Mayhew, K. Michel, A. Mori, N. Liu, H. Naveira, V. Nene, N. Nguyen, M. D. Pearson, E. J. Pritham, D. Puiu, Y. Qi, H. Ranson, J. M. Ribeiro, H. M. Roberston, D. W. Severson, M. Shumway, M. Stanke, R. L. Strausberg, C. Sun, G. Sutton, Z. J. Tu, J. M. Tubio, M. F. Unger, D. L. Vanlandingham, A. J. Vilella, O. White, J. R. White, C. S. Wondji, J. Wortman, E. M. Zdobnov, B. Birren, B. M. Christensen, F. H. Collins, A. Cornel, G. Dimopoulos, L. I. Hannick, S. Higgs, G. C. Lanzaro, D. Lawson, N. H. Lee, M. A. Muskavitch, A. S. Raikhel, P. W. Atkinson Science, 6000, 2010.
  • Aedes aegypti uses RNA interference in defense against Sindbis virus infectionCorey C. Rosenberg, K. M. Keene, Doug E. Brackney, Kenneth E. Olson, Carol D. Brennan, Jeffrey Wilusz, Brian D. Foy BMC Microbiol, 2008.
  • Comparative genomics of small RNA regulatory pathway components in vector mosquitoesCorey C. Rosenberg, William C. Black IV, Ann Marie Hess, Brian D. Foy BMC Genomics, 2008.