Colorado State University

Our laboratory is a unique academic-industry hybrid uniting the expertise and clinical success of Assisted Reproductive Technologies (ART) and advances in Cell & Gene Therapy (CGT). Our research program integrates decades of knowledge from these two distinct, but related fields to create transformative next generation culture media and biosolutions that address pressing challenges in both areas. As the research & development (R&D) arm of CaseBioscience, our work is squarely aimed at developing commercial products that will benefit researchers and clinicians in ART and CGT. To achieve this aim, we delve deeply into the molecular mechanisms of cell metabolism and stress pathways, the differentiation states and physiology of stem cells, immune cells, and other human cells poised for applications in cell therapy and regenerative medicine. Current projects include investigating novel approaches to cryopreservation, improving physiological stem cell cultivation, and developing next generation embryo culture medium for assisted reproduction. A major goal is focused on improving long-term survival and physiology of stem cells and immune cells during cryopreservation, a necessary step in the widespread adoption of cell therapies. Other R&D projects are aimed at developing next generation, physiological cell culture media for human pluripotent stem cells, a pivotal cell type for CGT, and human embryos, essential for enhancing assisted reproduction outcomes. With the ultimate goal of developing clinical biosolutions, we follow ISO13485 procedures for medical device manufacturing, providing a distinct environment for translational research.