Soham Chanda Assistant Professor

Office: Mrb 279

Phone: (970) 491-7004

Website: https://sites.google.com/view/sohamchanda

Education

  • PhD, State University of New York at Buffalo

About

Our research objectives fall in the intersection of basic and translational neuroscience. We broadly study several aspects of the neurodevelopmental process, e.g. cellular mechanisms that regulate neuronal function, molecular contributions that determine neuronal specifications, and pathogenic effects of disease-associated mutations that impair neuronal properties. We are also interested in developing novel protocols to directly convert non-neuronal somatic cells or embryonic/induced pluripotent stem (ES/iPS, respectively) cells into human neurons, and using these transdifferentiated neurons to gain mechanistic insights into human neurodevelopment and neurological disorders. Our work employs interdisciplinary approaches, e.g. cellular reprogramming, electrophysiology, high-resolution imaging, molecular biology, gene-expression, and biochemical analyses.

Publications

Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human NeuronsMarro SG*, Chanda S*, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, Kalani MYS, Südhof TC, and Wernig MNeuron, 2019PMID: 31257103
Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced TeratogenicityChanda S*, Ang CE, Lee QY, Ghebrial M, Haag D, Shibuya Y, Wernig M, and Südhof TC*Cell Stem Cell, 2019PMID: 31155484
Transdifferentiation of human adult peripheral blood T cells into neuronsTanabe K*, Ang CE*, Chanda S, Olmos VH, Haag D, Levinson DF, Südhof TC, and Wernig MProc Natl Acad Sci USA, 2018PMID: 29866841
Unique versus redundant functions of Neuroligin genes in shaping excitatory and inhibitory synapse propertiesChanda S*, Hale WD, Zhang B, Wernig M, and Südhof TCJ Neurosci, 2017PMID: 28607166
Generation of pure GABAergic neurons by transcription factor programmingYang N*, Chanda S*, Marro S, Ng YH, Janas JA, Haag D, Ang CE, Tang Y, Flores Q, Mall M, Wapinski O, Li M, Ahlenius H, Rubenstein JL, Chang HY, Buylla AA, Südhof TC, and Wernig MNature Methods, 2017PMID: 28504679
Myt1l safeguards neuronal identity by actively repressing many non-neuronal fatesMall M, Kareta MS, Chanda S, Ahlenius H, Perotti N, Zhou B, Grieder SD, Ge X, Drake S, Ang CE, Walker BM, Vierbuchen T, Fuentes DR, Brennecke P, Nitta KR, Jolma A, Steinmetz LM, Taipale J, Südhof TC, and Wernig M.Nature, 2017PMID: 28379941
FoxO3 regulates neuronal reprogramming of cells from postnatal and aging miceAhlenius H*, Chanda S*, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Südhof TC, Wernig MProc Natl Acad Sci USA, 2016PMID: 27402759
Pathogenic mechanism of an autism-associated Neuroligin mutation involves altered AMPA-receptor trafficking.Chanda S, Aoto J, Lee S, Wernig M, and Südhof TCMol Psychiatry, 2015PMID: 25778475
Generation of induced neuronal cells by the single reprogramming factor Ascl1Chanda S*, Ang CE*, Davila J*, Pak C, Mall M, Lee QY, Ahlenius H, Jung SW, Südhof TC and Wernig MStem Cell Reports, 2014PMID: 25254342
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutationChanda S, Marro S, Wernig M, and Südhof TC. Proc Natl Acad Sci USA, 2013PMID: 24046374