Office: Molecular Radiological Bioscie Radiological Biosciences (MRB) 279
Phone: (970) 491-7004
Website: https://sites.google.com/view/sohamchanda
Education
- PhD, State University of New York at Buffalo
About
Our research objectives fall in the intersection of basic and translational neuroscience. We broadly study various aspects of the synapse formation and maturation processes, including cellular mechanisms that modulate synapse properties, molecular factors that define synaptic specification, and pathogenic effects of disease-associated genetic mutations that impair synapse function. We address these questions using animal models and human neurons derived from embryonic or induced pluripotent stem (ES or iPS) cells. Our studies combine interdisciplinary approaches, including genetic manipulation, electrophysiology, high-resolution imaging, molecular and biochemical techniques, to gain mechanistic insights into human synapse development and neurological disorders.
Publications
- Presynaptic trafficking of Glutamate Decarboxylase isoforms is dispensable for basal GABAergic neurotransmissionJ Neurosci, 2026PMID: 41249058
- The Shab family potassium channels are highly enriched at the presynaptic terminals of human neuronsJ Biol Chem, 2025PMID: 39880095
- Gephyrin promotes autonomous assembly and synaptic localization of GABAergic postsynaptic components without presynaptic GABA releaseProc Natl Acad Sci USA, 2024PMID: 38889143
- Multiple N-linked glycosylation sites critically modulate the synaptic abundance of Neuroligin isoformsJ Biol Chem, 2023PMID: 37865312
- Induction of synapse formation by de novo neurotransmitter synthesisNat Commun, 2022PMID: 35650274
- An autism-associated mutation impairs Neuroligin-4 glycosylation and enhances excitatory synaptic transmission in human neuronsJ Neurosci, 2021PMID: 33268543
- Direct reprogramming of human neurons identifies MARCKSL1 as a pathogenic mediator of valproic acid-induced teratogenicityCell Stem Cell, 2019PMID: 31155484
