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Office: Anatomy and Zoology (AZ) E206F

Phone: 9704914963

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Research– Trancriptional regulation of arbovirus susceptibility in mosquitoes

Arboviruses require an intermediate vector, eg, mosquitoes (arthropods), in order to be transmitted to vertebrates and humans. Aedes aegypti is a major vector of flavivirus pathogens, e.g., dengue, Zika, chikungunya viruses and is also competent for transmission of Rift Valley Fever virus (RVFV). Culex tarsalis transmits West Nile virus and is also highly competent for transmission of RVFV in the lab. Mosquitoes show wide variability in differential gene expression patterns in response to arboviruses.

When arthropod-borne viruses (arboviruses) are delivered to vector mosquitoes in an infectious bloodmeal, viral components interact with host proteins to hijack cells and initiate replication. The extent to which arbovirus infection alters mosquito host transcriptional and chromatin regulatory processes to promote viral propagation is currently unknown. Culex and Aedes species transmit important exotic zoonotic arboviruses, e.g. RVFV, of potential concern to U.S. animal and public health. The objective of our current project is to identify features of transcriptional regulation in mosquito genomes that contribute to vector competence. We are especially interested in whether these regulatory regions are part of mosquito antiviral defense or are hijacked by viral proteins to enhance viral propagation and transmission.

I use my maiden name, CL Campbell, in publications. 

 

Publications

  • “Exome-wide association of deltamethrin resistance in Aedes aegypti from Mexico” Saavedra-Rodriguez K, Campbell CL, Lenhart A, Penilla P, Lozano-Fuentes S, Black WC 4th Insect Mol Biol. 2019 Feb 13., 2019
  • “Vgsc-interacting proteins are genetically associated with pyrethroid resistance in Aedes aegypti.” Campbell CL, Saavedra-Rodriguez K, Kubik TD, Lenhart A, Lozano-Fuentes S, Black WC 4th. PLoS One. 2019 Jan 29;14(1):e0211497., 2019
  • “Improved reference genome of Aedes aegypti informs arbovirus vector control.” Matthews BJ, Dudchenko O, Kingan SB, Koren S, Antoshechkin I, Crawford JE, Glassford WJ, Herre M, Redmond SN, Rose NH, Weedall GD, Wu Y, Batra SS, Brito-Sierra CA, Buckingham SD, Campbell CL, Chan S, Cox E, Evans BR, Fansiri T, Filipovi? I, Fontaine A, Gloria-Soria A, Hall R, Joardar VS, Jones AK, Kay RGG,Kodali VK, Lee J, Lycett GJ, Mitchell SN, Muehling J, Murphy MR, Omer AD, Partridge FA, Peluso P, Aiden AP, Ramasamy V, Raši? G, Roy S, Saavedra-Rodriguez K, Sharan S, Sharma A, Smith ML, Turner J, Weakley AM, Zhao Z, Akbari OS, Black WC 4th, Cao H, Darby AC, Hill CA, Johnston JS, Murphy TD, Raikhel AS, Sattelle DB, Sharakhov IV, White BJ, Zhao L, Aiden EL, Mann RS, Lambrechts L, Powell JR, Sharakhova MV, Tu Z, Robertson HM, McBride CS, Hastie AR, Korlach J, Neafsey DE, Phillippy AM, Vosshall LB. Nature. 2018 Nov;563(7732):501-507. doi:10.1038/s41586-018-0692-z. Epub 2018 Nov 14. PubMed PMID: 30429615, 2018
  • “Alternative patterns of sex chromosome differentiation in Aedes aegypti (L)” Campbell CL, Dickson LB, Lozano-Fuentes S, Juneja P, Jiggins FM, Black WC 4th. BMC Genomics. 2017 Dec 4;18(1):943. doi: 10.1186/s12864-017-4348-4. PubMed PMID:29202694; PubMed Central PMCID: PMC5716240., 2017
  • “Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico.” Saavedra-Rodriguez K, Maloof FV, Campbell CL, Garcia-Rejon J, Lenhart A, Penilla P, Rodriguez A, Sandoval AA, Flores AE, Ponce G, Lozano S, Black WC 4th Science Reports Apr 30;8(1):6747. doi: 10.1038/s41598-018-25222-0. PubMed PMID: 29712956, 2018
  • “Pathogenesis and host response to a novel Tacaribe virus isolate in experimentally-infected Jamaican fruit bats” Phillida A Charley 1, Luke Namesnik 1, Paul S Soma 1, Ashley B Reers 2, Clara Reasoner 1, Shijun Zhan 1, Bradly Burke 1, Liliana M Dávalos 3, Jan Felix Drexler 4, Allison C Vilander 1, Rushika Perera 1, Hannah K Frank 2, Corey L Campbell 1, Tony Schountz 1 , 2026
  • “Altered histone modifications in Aedes aegypti midguts following Rift Valley fever virus exposure” Hunter A. Ogg, Zoey M. Mikol, David C. King, Chad E. Mire, Zeyad Arhouma, Erin Osborne Nishimura, Rebekah C. Kading & Corey L. Campbell , 2026