Office: Molecular Radiological Bioscie 231
Phone: 9704912695
Education:
- Ph.D. Molecular Biophysics and Structural Biology, University of Pittsburgh and Carnegie Mellon University
Website: https://schauerlab.colostate.edu/
Google Scholar: View Google Scholar Profile
About
Challenges to DNA replication, called replication stress, pose major risks to genome fidelity. Our lab studies the molecular mechanisms of various replication-coupled machines that help achieve accurate and efficient chromosome duplication in the face of such stress. We want to understand not only how these defense mechanisms operate to keep cells safe, but also how to potentialy disable these protective mechanisms during therapy that targets hyperoliferative cancer cells undergoing DNA replication. Current research topics include the replication checkpoint apparatus, replication-coupled translesion synthesis, and conflicts between replication forks with transcription bubbles and other R-loop proteins. We study these mechanisms in detail with traditional biochemistry involving reconstitution of replication from purified protein complexes, single-molecule fluorescence, genetic assays, and cell biology.
I currently teach BC411 and BC511 (Physical Biochemistry) and BC512 (Principles of Macromolecular Structure). I have previously taught BC404 (Comprehensive Biochemistry Lab) as BC563 (Molecular Genetics).
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